This method has been used in medical treatment and was first experimented in the treatment of cross-eyes, followed by trials for hemifacial spasms, cervical dystony, and spasticity in the subsequent years. Botox application in aesthetic surgery has recently been popular, by which it has been possible to eliminate wrinkles associated with excessive use of facial mimic muscles. To this end, the procedure is most commonly performed for wrinkles around the eyes, on the forehead, and between the eyebrows. It can, however, be used for wrinkles on the other parts of the face and neck. The aim is to stop the contractions of hyperactive mimic muscles temporarily. Consequently, the contractions leading to wrinkles that should not have formed or possible future wrinkles are prevented. It is best when botox therapy applied before the wrinkles become permanent features of the face. Nevertheless, botox therapy has limited effects on reversing the wrinkles that are present even when the individual is relaxed or asleep (this type of wrinkles require therapy with filling material). Contractions in the area of injection are stopped for 6 months. In other words; its effect lasts only 6 months; however, repeated applications extends the effective period, and the effects will also be more marked.


Botox is available in 100-U flacons in crystalline form. It is diluted in 1-cc serum physiologic solution. Thus, a solution of 100U toxin per 1 cc is obtained. After the solution is prepared, it must be used within 24 hours. The areas of active muscle contractions are identified, and small doses of the solution are injected into these areas with an insulin syringe. Each area receives a mean of 2-4 injections, each of which contains nearly 4U toxin (into the mimic muscle right under the skin).


No anesthesia is required. The procedure lasts only 5-10 minutes. There may be some redness in the area of injection. The patient can immediately return to his/her daily life; but is instructed not to massage the injection area but use the mimic muscles. The actual effect is observed in 4-5 days, and maximum effect is obtained in 1 month, lasting as long as 6 months. When the effect is lost, the patient will regain his or her earlier appearance. Repeated applications will prolong as well as render the effect permanent.

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